Atopic Dermatitis – Eczema and Skin barrier mutations

Skin Analysis
19 Nov 2013

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Skin barrier gene mutations are associated with atopic dermatitis epidermal water loss. In a recent study 619 exclusively breastfed babies were recruited at 3 months of age and examined for Atopic Dermatitis, and screened for the common skin gene mutations. Epidermal water loss was measured on unaffected forearm skin. In addition, skin prick testing was performed to six study foods (cow?s milk, egg, cod, wheat, sesame, and peanut). Children with atopic dermatitis were significantly more likely to react to the allergens. There was also a strong association between food sensitization and severity of the atopic dermatitis. The outcome of this recent study was that Atopic Dermatitis is the main skin-related risk factor for food sensitization in young infants. In exclusively breastfed children, this suggests that allergic sensitization to foods can be mediated by cutaneous antigen-presenting cells. (Journal of Investigative Dermatology (18 July 2013) | doi:10.1038/jid.2013.298)

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