The link between Staphylococcus aureus and allergic Skin Disease and what you can do about it
Atopic dermatitis is a chronic inflammatory skin disease that affects 15?30% of children and approximately 5% of adults in industrialized countries. Although the pathogenesis of atopic dermatitis is not fully understood, the disease is mediated by an abnormal immunoglobulin-E immune response in the setting of skin barrier dysfunction. Mast cells contribute to immunoglobulin-E-mediated allergic disorders including atopic dermatitis. More than 90% of patients with atopic dermatitis are colonized with Staphylococcus aureus in the lesional skin whereas most healthy individuals do not harbour the pathogen. Several staphylococcal exotoxins can act as superantigens and/or antigens in models of atopic dermatitis. The culture of S. aureus contain and biochemical analysis identified the ?-toxin or produced by S. aureus. Furthermore, S. aureus isolates recovered from patients with atopic dermatitis produced large amounts of ?-toxin. Skin colonization with S. aureus, promoted inflammatory skin disease. Studies identify S. aureus colonization as a potent inducer allergic skin disease. Therefore it is important to analyse your skin through a skin culture prior prescribing treatment.